CD3 antibody [17A2], IgG2b, Unconjugated, Rat, Monoclonal
Catalog Number:
GTX01458
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| Article Name: | CD3 antibody [17A2], IgG2b, Unconjugated, Rat, Monoclonal |
| Biozol Catalog Number: | GTX01458 |
| Supplier Catalog Number: | GTX01458 |
| Alternative Catalog Number: | GTX01458-100 |
| Manufacturer: | GeneTex |
| Host: | Rat |
| Category: | Antikörper |
| Application: | Depletion, FC, IHC-Fr, IP |
| Species Reactivity: | Mouse |
| Conjugation: | Unconjugated |
| Alternative Names: | CD3 antigen, delta polypeptide , CD3 antigen, epsilon polypeptide , CD3 antigen, gamma polypeptide , CD247 antigen , T3d , AI504783 , CD3 , CD3epsilon , T3e , Ctg-3 , Ctg3 , T3g , 4930549J05Rik , A430104F18Rik , AW552088 , Cd3 , Cd3-eta , Cd3-zeta , Cd3h , Cd3z , Cd3zeta , T3z , Tcrk , Tcrz |
| The 17A2 antibody reacts with the mouse CD3 complex, comprised of CD3 epsilon, CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 17A2 antibody is a widely used phenotypic marker for mouse T cells. In addition, as the CD3e chain within the TCR complex contains intracellular signaling domains, binding of 17A2 antibody to CD3 can induce cell activation (use format suitable for functional assays). |
| Application Notes: | *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
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