c-Kit antibody [ACK2] (PE), IgG2b, Rat, Monoclonal
Biozol Catalog Number:
GTX01469-08
Supplier Catalog Number:
GTX01469-08
Alternative Catalog Number:
GTX01469-08-100
Manufacturer:
GeneTex
Host:
Rat
Category:
Antikörper
Application:
FC
Species Reactivity:
Mouse
Conjugation:
PE
The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo.
Clonality:
Monoclonal
Concentration:
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
