The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state - present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.
Clonality:
Monoclonal
Concentration:
0.025 mg/ml (Please refer to the vial label for the specific concentration.)
FCM: 0.125 µg (5 µl) for 105-108 cells in 100 µl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
* VAT and and shipping costs not included. Errors and price changes excepted
