Tertiapin Q, CAS [[910044-56-3]]

Product Overview

• Article Name: Tertiapin Q, CAS [[910044-56-3]]
• Biozol Catalog Number: ISC-KC-010
• Supplier Catalog Number: KC-010
• Alternative Catalog Number: ISC-KC-010
• Manufacturer: Isca Biochemicals
• Category: Biochemikalien
• Alternative Names: TPNQ, TPN(Q)

Product Description

Tertiapin-Q is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q is a stable derivative of the bee venom toxin tertiapin where the methionine residue at position 13 has been replaced with glutamine, which is far less susceptible to oxidation by air. Tertiapin-Q and native tertiapin have very similar pharmacologucal properties. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and shows selectivity over Kir2.1 channels.

Product Properties

• Molecular Weight: 2452
• NCBI: 1999
• Purity: >95% by hplc
• Form: Freeze dried solid
• Sequence: H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2: disulphide bridges between Cys-3 and Cys-14 and Cys-5 and Cys-18
• CAS Number: [910044-56-3]
• Formula: C106H175N35O24S4
• Target: Potassium channels

Application Notes

• Application Notes: ProductType: Peptides