Y 27632 is a selective inhibitor of the Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases, with Kis of 140 nM and 300nM against ROCK1 and ROCK2 respectively, and greater than 200-fold selectivity over other kinases. Y 27632 is cell-permeable, orally bioavailable and active in vivo, and can enhance stem cell survival and proliferation in culture. In combination with other agents, Y 27632 can be used to reprogram fibroblasts to mature neurons and can optimise naive human pluripotent stem cell (iSPC) growth and viability. Y 27632 has been used used to generate brain organoids from iPSCs.
Molecular Weight:
320.26
Purity:
99% by HPLC, NMR conforms
Form:
White solid
CAS Number:
[129830-38-2]
Formula:
C14H21N3O.2HCl
Target:
Kinases
Application Notes:
ProductType: Small molecules
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