Myr-tat-CBD3

Product Overview

• Article Name: Myr-tat-CBD3
• Biozol Catalog Number: ISC-PP-180
• Supplier Catalog Number: PP-180
• Alternative Catalog Number: ISC-PP-180
• Manufacturer: Isca Biochemicals
• Category: Biochemikalien

Product Description

Myr-tat-CBD3 is the N-terminal myristoylated version of TAT-CBD3 (PP-140), a peptide derived from the axonal collapsin response mediator protein 2 (CRMP-2). The myristoyl group allows insertion of myr-tat-CBD3 into membranes through hydrophobic interactions and myr-tat-CBD3 is membrane tethered, restricts the CaV2.2 -CRMP2 interaction, blocks CaV2.2 trafficking, and strongly inhibits Ca2+ influx from primary sensory neurons. Intrathecal injection of myr-tat-CBD3 reduces carrageenan-induced inflammation and reverses paw incision -induced thermal and mechanical hypersensitivity without producing rewarding behaviour.

Product Properties

• Molecular Weight: 3459.2
• NCBI: 2011
• Purity: >95% by HPLC
• Form: Freeze dried solid
• Sequence: Myr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Arg-Ser-Arg-Leu-Ala-Glu-Leu-Arg-Gly-Val-Pro-Arg-Gly-Leu-OH
• Formula: C148H269N59O33
• Target: Protein-protein interactions,Calcium channels,Transient receptor potential (TRP) channels

Application Notes

• Application Notes: ProductType: Cell penetrating peptides