P140 is a peptide from the small nuclear ribonucleoprotein U1-70K, phosphorylated at the Ser140 position. P140 binds to the HSPA8/HSC70 chaperone protein, a constitutively expressed, cognate protein of the HSP70 family, which is involved in many cellular processes and has a key regulatory role in autophagy. Both in vitro and in vivo, P140 interferes with hyperactivated chaperone-mediated autophagy, modifying overexpression of major histocompatibility complex class II molecules and antigen presentation to autoreactive T cells. In a lupus prone murine model, P140 displays tolerogenic and immunomodulatory effects, depleting hyperactivated autoreactive T and B cells and restoring normal immune homeostasis. P140 decreases proteinuria and anti-DNA antibody production, and significantly prolongs survival.
Molecular Weight:
2638.94
Purity:
>95% by hplc
Form:
Freeze dried solid
Sequence:
RIHMVYSKRS(PO3)GKPRGYAFIEY
CAS Number:
[497156-60-2]
Formula:
C117H181N32O32PS
Target:
Protein-protein interactions
Application Notes:
ProductType: Peptides
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