Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, CAS [[438625-61-7]]

Product Overview

• Article Name: Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, CAS [[438625-61-7]]
• Biozol Catalog Number: ISC-PS-020
• Supplier Catalog Number: PS-020
• Alternative Catalog Number: ISC-PS-020
• Manufacturer: Isca Biochemicals
• Category: Biochemikalien
• Alternative Names: Mca-(Asn,Leu)-Amyloid beta/A4 Protein Precursor,,,€ (667-676)-Lys(Dnp)-Arg-Arg amide

Product Description

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, also knowm as Mca-(Asn,Leu)-Amyloid beta/A4 Protein Precursor,,,€ (667-676)-Lys(Dnp)-Arg-Arg amide, is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the Swedish Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) beta-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

Product Properties

• Molecular Weight: 2001.1
• NCBI: 1999
• Purity: >95% by HPLC
• Form: Freeze dried solid
• Sequence: Mca-SEVNLDAEFR-K(Dnp)-RR-NH2
• CAS Number: [438625-61-7]
• Formula: C86H125N27O29
• Target: Secretases

Application Notes

• Application Notes: ProductType: Fluorescent labelled peptides