A 83-01 is a potent inhibitor of TGF-beta type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM respectively, and only weak inhibition of ALK-1, -2, -3, -6 and MAPK. A 83-01 inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. A 83-01 helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (hPSCs) and also promotes neural differentiation of hPSCs as part of a chemical cocktail.
Molecular Weight:
421.53
Purity:
98% by TLC, NMR conforms
Form:
Light yellow solid
CAS Number:
[909910-43-6]
Formula:
C25H19N5S
Target:
Receptor serine/threonine kinase receptors
Application Notes:
ProductType: Small molecules
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