Human ALK-1/ACVRL1 Protein (ALK-HM101)

Product Overview

• Article Name: Human ALK-1/ACVRL1 Protein (ALK-HM101)
• Biozol Catalog Number: KAB-ALK-HM101
• Supplier Catalog Number: ALK-HM101
• Alternative Catalog Number: KAB-ALK-HM101-100UG, KAB-ALK-HM101-500UG
• Manufacturer: KactusBio
• Category: Proteine/Peptide
• Species Reactivity: Human
• Alternative Names: ACVRLK1, ORW2, ALK1, ALK-1, EC 2.7.11, HHT, HHT2, SKR3, TSR-I, ACVRL1, Activin RLI,Activin RL1

Product Description

Recombinant Human ALK-1/ACVRL1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp22-Gln118.

Product Properties

• Molecular Weight: The protein has a predicted MW of 11.5 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
• Tag: C-His
• UniProt: P37023
• Buffer: Lyophilized from 0.22µm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
• Expression System: HEK293
• Purity: > 95% as determined by Bis-Tris PAGE,> 95% as determined by HPLC
• Form: Lyophilized
• Sequence: Asp22-Gln118
• Target: ALK-1/ACVRL1

Images

Human ALK-1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human ALK-1 is greater than 95% as determined by SEC-HPLC.

Immobilized Human GDF-2, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human ALK-1, His Tag with the EC50 of 33.1ng/ml determined by ELISA (QC Test).

Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50-for this effect is <50 ng/mL in the presence of 2 ng/mL of recombinant human BMP9 (Cat.GDF-HM002).