Vaccinia Capping Enzyme, GMP-Grade (GMP-VCS-VE101), DMF 038028 - Preis auf Anfrage
Catalog Number:
KAB-GMP-VCS-VE101
| Article Name: |
Vaccinia Capping Enzyme, GMP-Grade (GMP-VCS-VE101), DMF 038028 - Preis auf Anfrage |
| Biozol Catalog Number: |
KAB-GMP-VCS-VE101 |
| Supplier Catalog Number: |
GMP-VCS-VE101 |
| Alternative Catalog Number: |
KAB-GMP-VCS-VE101-10KU, KAB-GMP-VCS-VE101-1MU |
| Manufacturer: |
KactusBio |
| Category: |
Proteine/Peptide |
| The 7-methylguanosine cap structure (m7Gppp, Cap0) is a specific feature in eukaryotic mRNA, which is required for mRNA stability, splicing, nuclear export, effective translation, and mRNA decay. Vaccinia Capping Enzyme, a heterodimer of D1 and D12 subunits, adding the Cap0 structure to the 5 end of the RNA. The D1 subunit comprises an N-terminal RNA triphosphatase (TPase), a guanylyltransferase (GTase), and a C-terminal guanine-N7-methyltransferase (MTase). The D12 subunit binds and stimulates the MTase. NOTE: mRNA Cap 2-O-Methyltransferase (Kactus GMP-MEH-VE101) is required to generate Cap 1 structure that reduces cellular innate immune response when the RNA is used in vivo . This product has been filed with the FDA Drug Master Files (DMF) and is assigned DMF 038028. |
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Figure 1. Analysis of mRNA capping efficiency using LC-MS. |
