Human TGF-beta RII/TGFBR2 Protein (TGF-HM5R2)

Product Overview

• Article Name: Human TGF-beta RII/TGFBR2 Protein (TGF-HM5R2)
• Biozol Catalog Number: KAB-TGF-HM5R2
• Supplier Catalog Number: TGF-HM5R2
• Alternative Catalog Number: KAB-TGF-HM5R2-100UG, KAB-TGF-HM5R2-500UG
• Manufacturer: KactusBio
• Category: Proteine/Peptide
• Species Reactivity: Human
• Alternative Names: TGFR2, TGFBR2, TbetaR-II, TGFbetaR2, TbetaR-II, TGFbetaR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TbetaR-II, TbetaR-II

Product Description

Recombinant Human TGF-beta RII/TGFBR2 Protein is expressed from HEK293 with hFc (IgG1) tag at the N-Terminus.It contains Ile24-Asp159.

Product Properties

• Molecular Weight: The protein has a predicted MW of 44.2 kDa. Due to glycosylation, the protein migrates to 50-68 kDa based on Bis-Tris PAGE result.
• Tag: N-hFc (IgG1)
• UniProt: P37173
• Buffer: Lyophilized from 0.22µm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
• Expression System: HEK293
• Purity: > 95% as determined by Bis-Tris PAGE,> 95% as determined by HPLC
• Form: Lyophilized
• Sequence: Ile24-Asp159
• Target: TGF-beta RII/TGFBR2

Images

Human TGF-beta RII on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Human TGF-beta RII is greater than 95% as determined by SEC-HPLC.

Human TGF-beta RII, hFc Tag captured on CM5 Chip via Protein A can bind Human Latent TGF beta 2, His Tag with an affinity constant of 2.21 uM as determined in SPR assay (Biacore T200).

Immobilized Human Mature TGF beta 1, No Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human TGF-beta RII, hFc Tag with the EC50 of 11.0ng/ml determined by ELISA (QC Test).

Loaded Human TGF-beta RII, hFc Tag on ProA-Biosensor can bind Human Mature TGF beta 3, No Tag with an affinity constant of 0.51 nM as determined in BLI assay (Gator Prime).