Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 µM (rat brain) for COX and 100 µM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.
Molecular Weight:
365.50
CAS Number:
[71079-19-1]
Formula:
C20H23N5S
Target:
COX
Application Notes:
Reference compound
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