SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents[1][2].
Molecular Weight:
382.85
Purity:
98.04
CAS Number:
[1184843-57-9]
Formula:
C19H19ClN6O
Target:
Checkpoint Kinase (Chk)
Application Notes:
Reference compound
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