Varenicline-d4 hydrochloride is a deuterium labeled Varenicline (dihydrochloride) (HY-10019A)[1]. Varenicline (CP 526555) dihydrochloride is a potent partial agonist for alpha4beta2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 µM. Varenicline dihydrochloride is a full agonist for alpha3beta4 and alpha7 nAChRs with EC50 values of 55 µM and 18 µM, respectively[2]. Varenicline dihydrochloride is a nicotinic ligand based on the structure of cytosine, and has the potential for smoking cessation treatment[3].
Formula:
C13H9D4N3.xHCl
Target:
Isotope-Labeled Compounds,nAChR
Application Notes:
Isotope-Labeled Compounds
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