Varenicline (CP 526555) is an orally active partial agonist of alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2 nAChR, IC50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of alpha6beta2 nAChR and a full agonist of alpha6beta2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation[1][2][3][4][5].
Molecular Weight:
361.35
Purity:
99.96
CAS Number:
[375815-87-5]
Formula:
C17H19N3O6
Target:
ERK,nAChR,p38 MAPK
Application Notes:
Reference compound
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