RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].
Molecular Weight:
440.88
Purity:
99.87
CAS Number:
[1219810-16-8]
Formula:
C23H21ClN2O5
Target:
Ferroptosis,Glutathione Peroxidase,p62,Reactive Oxygen Species (ROS)
Application Notes:
Reference compound
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