Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas[1][2].
Molecular Weight:
581.49
Purity:
99.00
CAS Number:
[675576-98-4]
Formula:
C30H30Cl2N4O4
Target:
Apoptosis,Autophagy,E1/E2/E3 Enzyme,MDM-2/p53
Application Notes:
Reference compound
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