PF 477736, CAS [[952021-60-2]]

Product Overview

• Article Name: PF 477736, CAS [[952021-60-2]]
• Biozol Catalog Number: MCE-HY-10032
• Supplier Catalog Number: HY-10032
• Alternative Catalog Number: MCE-HY-10032-25MG,MCE-HY-10032-5MG,MCE-HY-10032-50MG,MCE-HY-10032-1MG,MCE-HY-10032-100MG,MCE-HY-10032-10MMX1ML,MCE-HY-10032-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: PF 00477736

Product Description

PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2].

Product Properties

• Molecular Weight: 419.48
• Purity: 99.04
• CAS Number: [952021-60-2]
• Formula: C22H25N7O2
• Target: Aurora Kinase,CDK,c-Fms,Checkpoint Kinase (Chk),FGFR,FLT3,RET,Src,VEGFR

Application Notes

• Application Notes: MCE Product type: Reference compound