CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn[1].
Molecular Weight:
961.18
Purity:
99.88
CAS Number:
[1202758-21-1]
Formula:
C48H68N10O9S
Target:
Btk
Application Notes:
MCE Product type: Reference compound
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