MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRalpha with IC50s of 0.18, 0.19, and 0.42 µM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].
Molecular Weight:
432.56
Purity:
98.32
CAS Number:
[1922153-17-0]
Formula:
C25H32N6O
Target:
Haspin Kinase,MELK,Mitosis,PDGFR
Application Notes:
Reference compound
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