Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis[1][2].
Molecular Weight:
587.17
Purity:
99.76
CAS Number:
[136668-42-3]
Formula:
C34H35ClN2O3S
Target:
Apoptosis,FLAP
Application Notes:
Reference compound
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