NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC501.59 µM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntingtons disease transgenic mice[1][2][3].
Molecular Weight:
325.40
Purity:
97.26
CAS Number:
[537034-15-4]
Formula:
C19H23N3O2
Target:
HDAC
Application Notes:
Reference compound
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