SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 µM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 µM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth[1][2].
Molecular Weight:
352.26
Purity:
99.81
CAS Number:
[1801747-42-1]
Formula:
C16H19Cl2N5
Target:
Phosphatase,SHP2
Application Notes:
Reference compound
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