CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1].
Molecular Weight:
278.31
Purity:
98.95
CAS Number:
[1628208-23-0]
Formula:
C16H14N4O
Target:
Histone Demethylase
Application Notes:
Reference compound
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