Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines[1].
Molecular Weight:
428.29
Purity:
99.84
CAS Number:
[1642300-52-4]
Formula:
C17H10F6N6O
Target:
CRM1
Application Notes:
Reference compound
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