IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 µM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].
Molecular Weight:
353.41
Purity:
98.95
CAS Number:
[310456-65-6]
Formula:
C15H15NO5S2
Target:
Notch
Application Notes:
Reference compound
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