PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy[1].
Molecular Weight:
554.85
CAS Number:
[1268245-19-7]
Formula:
C29H22Cl3NO4
Target:
FXR
Application Notes:
Reference compound
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