SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-beta1. SIS3 free base does not affect the phosphorylation of Smad2[1].
Molecular Weight:
453.53
Purity:
98.02
CAS Number:
[521985-36-4]
Formula:
C28H27N3O3
Target:
TGF-beta/Smad
Application Notes:
Reference compound
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