CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90alpha, with Kd of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC50 values of 0.098 and 0.066 µM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%). CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model[1][2].
Molecular Weight:
415.90
Purity:
99.05
CAS Number:
[959763-06-5]
Formula:
C19H18ClN5O2S
Target:
HSP
Application Notes:
MCE Product type: Reference compound1
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