(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS)-4CPG (500µM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.61.7% (n = 8) in IP3R1(-/-) mice and 116.91.8% (n = 5) in IP3R1(+/+) mice.
Molecular Weight:
195.17
Purity:
99.04
CAS Number:
[7292-81-1]
Formula:
C9H9NO4
Target:
mGluR
Application Notes:
Reference compound
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