Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptor. The affinity (Kis) of Lesogaberan hydrochloride for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5.1 nM and 1.4 µM, respectively. Lesogaberan hydrochloride inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action[1].
Molecular Weight:
177.54
Purity:
98
CAS Number:
[2925644-17-1]
Formula:
C3H10ClFNO2P
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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