Desmethyl cariprazine is a major active metabolite of cariprazine, with activities at human dopamine receptors and serotonin receptors, showing a pEC50 of 8.90 at human D2 receptors, a pEC50 of 8.09 at D3 receptors, and a pEC50 of 6.28 at 5-HT1A receptors. Desmethyl cariprazine inhibits forskolin-induced cAMP production at D2, D3 and 5-HT1A receptors, and suppresses serotonin-induced Ca2+ release at 5-HT2B receptors. Desmethyl cariprazine is applicable to research related to schizophrenia, bipolar disorder type I and bipolar disorder.[1][2]
Molecular Weight:
413.38
Purity:
98.08
CAS Number:
[839712-15-1]
Formula:
C20H30Cl2N4O
Target:
5-HT Receptor,Dopamine Receptor
Application Notes:
MCE Product type: Reference compound
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