Y-27632 is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation[1][2][3][4][5][6][7].
Molecular Weight:
247.34
Purity:
99.91
CAS Number:
[146986-50-7]
Formula:
C14H21N3O
Target:
Apoptosis,Organoid,ROCK
Application Notes:
MCE Product type: Reference compound1
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