Lanabecestat (AZD-3293) hydrochloride is a potent BACE1 inhibitor that has been investigated for its potential as a modifying treatment for Alzheimers disease. Lanabecestat (hydrochloride) demonstrated significant dose- and time-dependent reductions in concentrations of amyloid beta peptides in plasma, cerebrospinal fluid, and brain. Lanabecestat (hydrochloride) was also shown to produce reductions in Abeta neuritic plaque burden without demonstrating clinical benefits or slowing the progression of Alzheimers disease pathophysiology.
Molecular Weight:
448.99
CAS Number:
[1383986-31-9]
Formula:
C26H29ClN4O
Target:
Beta-secretase
Application Notes:
Reference compound
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