Ritlecitinib (tosylate) (Standard), CAS [[2192215-81-7]] Preis auf Anfrage

Product Overview

• Article Name: Ritlecitinib (tosylate) (Standard), CAS [[2192215-81-7]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-100754CR
• Supplier Catalog Number: HY-100754CR
• Alternative Catalog Number: MCE-HY-100754CR-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Ritlecitinib (tosylate) (Standard) is the analytical standard of Ritlecitinib (tosylate) (HY-100754C). This product is intended for research and analytical applications. Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 µ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE)[1][2][3].

Product Properties

• Molecular Weight: 457.55
• CAS Number: [2192215-81-7]
• Formula: C22H27N5O4S
• Target: Interleukin Related,JAK,Reference Standards,STAT

Application Notes

• Application Notes: MCE Product type: Reference Standards