BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].
Molecular Weight:
566.45
CAS Number:
[1818291-27-8]
Formula:
C30H26Cl2FN3O3
Target:
E1/E2/E3 Enzyme,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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