ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 µM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2].
Molecular Weight:
467.45
Purity:
99.90
CAS Number:
[1312471-39-8]
Formula:
C22H15F2N5O3S
Target:
Apoptosis,Mitosis,Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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