Saclofen is an orally active and a competitive GABAB receptor antagonist with an IC50 of 7.8 µM. Saclofen has weak antagonistic effects on GABAB1b and GABAB2 heterodimeric recombinant receptors. Saclofen inhibits the binding of Baclofen (HY-B0007) to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts, and exhibits anti-inflammatory and analgesic effects in rats[1][2][3][4][5].
Molecular Weight:
249.72
Purity:
99.82
CAS Number:
[125464-42-8]
Formula:
C9H12ClNO3S
Target:
GABA Receptor
Application Notes:
MCE Product type: Reference compound
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