Futibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor, with IC50s of 3.9, 1.3, 1.6, and 8.3 nM for FGFR 1-4, respectively. Futibatinib inhibits mutant and wild-type FGFR2 with similar IC50s (wild-type FGFR2=0.9 nM, V5651=1-3 nM, N550H=3.6 nM, E566G=2.4 nM)[1][2][3].
Molecular Weight:
418.45
Purity:
99.90
CAS Number:
[1448169-71-8]
Formula:
C22H22N6O3
Target:
FGFR
Application Notes:
MCE Product type: Reference compound
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