5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid reduces NMDA-induced neuron injury. 5,7-Dichlorokynurenic acid increases social interaction time, increases open arm exploration time, disinhibits suppressed conflict responding in rodent models. 5,7-Dichlorokynurenic acid exhibits anxiolytic-like activity in rodent models and supports exploration of glycines role in NMDA receptor-mediated synaptic transmission[1][2].
Molecular Weight:
258.06
Purity:
99.98
CAS Number:
[131123-76-7]
Formula:
C10H5Cl2NO3
Target:
iGluR
Application Notes:
MCE Product type: Reference compound
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