TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].
Molecular Weight:
580.68
Purity:
99.65
CAS Number:
[1603845-32-4]
Formula:
C32H36N8O3
Target:
EGFR
Application Notes:
MCE Product type: Reference compound1
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