JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research[1].
Molecular Weight:
354.34
Purity:
99.81
CAS Number:
[1918238-72-8]
Formula:
C18H15FN4O3
Target:
JAK
Application Notes:
MCE Product type: Reference compound
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