4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion[1][2][3].
Molecular Weight:
451.34
Purity:
99.96
CAS Number:
[1952-15-4]
Formula:
C21H26INO2
Target:
Apoptosis,EGFR,Interleukin Related,mAChR,MMP
Application Notes:
MCE Product type: Reference compound
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