BD-1008-d5 dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966). BD-1008 dihydrobromide is a nonselective sigma receptor antagonist with Kis against sigma1 receptor and sigma2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (Ki = 1112 nM) and dopamine transporter (DAT) (Ki > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the sigma2 receptor. BD-1008 dihydrobromide blocks the self-administration behavior of sigma agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the sigma receptor[1][2][3].
Molecular Weight:
468.11
Formula:
C15H19D5Br2Cl2N2
Target:
Isotope-Labeled Compounds,Sigma Receptor
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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