PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively. PF-06263276 inhibits pSTAT3 and TYK2 pathway. PF-06263276 has a protective effect against ear skin inflammation[1].
Molecular Weight:
566.63
Purity:
99
CAS Number:
[1421502-62-6]
Formula:
C31H31FN8O2
Target:
JAK,STAT
Application Notes:
MCE Product type: Reference compound
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