MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].
Molecular Weight:
498.55
Purity:
99.94
CAS Number:
[2083622-09-5]
Formula:
C28H27FN6O2
Target:
Apoptosis,NEKs
Application Notes:
MCE Product type: Reference compound1
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