AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 µM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 µM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
Molecular Weight:
280.28
Purity:
98.69
CAS Number:
[133550-35-3]
Formula:
C16H12N2O3
Target:
CDK,EGFR
Application Notes:
MCE Product type: Reference compound1
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