GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.
Molecular Weight:
398.26
CAS Number:
[2077980-80-2]
Formula:
C25H23BO4
Target:
Estrogen Receptor/ERR
Application Notes:
MCE Product type: Reference compound
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