Cyclothiazide is a positive allosteric modulator of ionotropic AMPA-type glutamate receptors. Cyclothiazide inhibits GABAA receptors. Cyclothiazide is frequently used to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Cyclothiazide can potentiate responses to kainate in hippocampal neurons. Cyclothiazide has effects on glutamatergic neurotransmission. Cyclothiazide also induces epileptiform EEG activity accompanying behavioral seizures[1][2][3][4].
Molecular Weight:
389.88
Purity:
98.78
CAS Number:
[2259-96-3]
Formula:
C14H16ClN3O4S2
Target:
GABA Receptor,iGluR
Application Notes:
Reference compound
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